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Natural compound in pomegranates, walnuts and blackberries improved heart function by 80 percent

Serdar HocamAuthor & Editor

Researchers at King's College London have determined that urolithin A, a compound formed by the consumption of pomegranates, walnuts and blackberries, improves heart function by 80 percent.

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Nar, ceviz ve böğürtlendeki doğal bileşik kalp fonksiyonları yüzde 80 iyileştirdi
İngiltere'deki King's College London bünyesinde yürütülen yeni bir kardiyoloji araştırması; nar, ceviz ve böğürtlen gibi meyvelerin sindirilmesiyle vücutta doğal olarak üretilen ‘ürolitin A’ adlı bileşiğin, tedavisi zor bir kalp yetmezliği türünde organ fonksiyonlarını yüzde 80'e varan oranda düzelttiğini ortaya koydu. Araştırmacılar, kalbin kan pompalama gücünü koruduğu ancak kas dokusunun sertleşmesi nedeniyle iki atım arasında gevşeyip yeterli kanla dolamadığı ‘korunmuş ejeksiyon fraksiyonlu kalp yetmezliği’ (HFpEF) tablosunu mercek altına aldı. Tüm kalp yetmezliği vakalarının yaklaşık yarısını oluşturan ve mevcut klasik ilaçların yetersiz kaldığı bu hastalık modelinde ürolitin A bileşiğinin etkisi incelendi.

A study conducted at King's College London in the UK found that urolithin A, a compound produced in the body through the digestion of fruits such as pomegranates, walnuts and blackberries, restored organ function by up to 80 percent in a specific type of heart failure.

Scope of the Research and Target Disease

The cardiology research conducted within King's College London focused on heart failure with preserved ejection fraction, a condition that is difficult to treat and accounts for half of the cases.

Mechanism of Action of Urolithin A Compound

Experiments revealed that the urolithin A molecule directly activates a protein called PKGlα, which plays a critical role in vascular health and the relaxation of the heart muscle.

It was observed that in subjects treated with the compound, heart functions improved by up to 80 percent, and the heart's ability to relax after contraction increased significantly.

Tests on Human Stem Cells

The scientific team also tested the molecule on artificial heart muscle tissue developed from human stem cells, demonstrating that the efficacy seen in animal models could also apply to the human heart.

Future Plans and Clinical Research

Dr. Joseph Burgoyne, the author of the research supported by the British Heart Foundation, stated that this disease is spreading with the aging population and obesity.

Experts reported that the results do not mean treatment simply by eating fruit, and that clinical trials will be initiated for new generation medications based on urolithin A.

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